SPECIFIC ANTIBODIES TO HALOTHANE-INDUCED LIVER ANTIGENS IN HALOTHANE-ASSOCIATED HEPATITIS
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چکیده
منابع مشابه
Halothane macrophage migration inhibtiion factor test in halothane-associated hepatitis.
As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis. Twenty-two subjects exposed to halothane, but with no evidence of jaundice, five 'healthy' hospital anaesthetists, nine jaundiced subjects without halothane exposure, and 10 healt...
متن کاملThe molecular basis of halothane-induced hepatitis.
Halothane hepatitis The anaesthetic agent halothane (CF,CHCIRr) causes two distinct types of liver damage. About 20% of halothane-exposed patients exhibit mild hepatotoxicity, characterized by transient elevations in liver enzymes. In contrast, a much smaller fraction of patients exposed to halothane (between 1 in 3500 and 1 in 35 000) develop severe hepatotoxicity, commonly termed ‘halothane h...
متن کاملHalothane and liver damage.
The Medical Assessor to the Committee on Safety ofMedicines recently issued' a letter entitled "Jaundice following repeated exposure to halothane," in which he noted that 130 reports of jaundice following anaesthesia had been received by the committee between 1964 and 1972, every case being associated with the use of halothane. Ninety-four of these patients had been exposed to halothane more th...
متن کاملHalothane and liver damage.
Halothane was first synthesized by Suckling in 1952 and introduced into clinical practice a few years later.',2 Its many advantages, such as quick action, easy administration, non-explosiveness, high potency and low cost, led to its widespread use within a short time. Although initial animal work did not indicate any hepatotoxic effect,3`5 the first cases of unexplained hepatitis after exposure...
متن کاملHalothane-induced hepatitis: A forgotten issue in developing countries
Halothane was introduced as an anesthetic in the 1950s and was considered a revolutionary agent in the field of anesthesia. Soon after, halothane-induced hepatitis became a concern, leading to the development of less toxic gases that induced a lower incidence of side effects. Two types of halothane-related hepatotoxicity have been described: type 1, or mild hepatitis, is associated with elevate...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1987
ISSN: 0007-0912
DOI: 10.1093/bja/59.10.1286